Pyrantel pamoate

Research use only, not for human use.

Pyrantel pamoate is a deworming agent in the treatment of hookworms (all species) and roundworms in domesticated animal.

Pyrantel pamoate is a deworming agent in the treatment of hookworms (all species) and roundworms in domesticated animal; acts as a depolarizing neuromuscular blocking agent.(In Vitro):Pyrantel pamoate (10 nM-10 μM; 72 h) shows good anti-A. suum and (0-168.2 M; 72 h) anti-N. americanus activity.(In Vivo):Pyrantel pamoate (10 mg/kg; p.o.; single) reduces the worms in A. ceylanicum-infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%.

Pyrantel pamoate (10 nM-10 μM; 72 h) shows good anti-A. suum and (0-168.2 M; 72 h) anti-N. americanus activity. Cell Viability Assay Cell Line:A. suum Concentration:10 nM-10 μM Incubation Time:72 h Result:Inhibited A. suum with a pEC50 value of 7.24.Cell Viability Assay Cell Line:N. americanus Concentration:0-168.2 M (0-100 μg/mL)Incubation Time:72 h Result:Inhibited third-stage larvae and adult of N. americanus with IC50 values of 2.0 and 7.6 mg/mL, respectively.

Pyrantel pamoate (10 mg/kg; p.o.; single) reduces the worms in A. ceylanicum-infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%. Animal Model:Male Syrian Golden hamsters (3-week-old; A. ceylanicum-infected).Dosage:10 mg/kg Administration:Oral administration; single.Result:Exhibited worm burden reduction and worm expulsion rates of 87.2% and 63.4%, respectively.

Pyrantel pamoate

Others

Other Targets

Antiparasitic

Infection

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22204-24-6

594.69

C34H30N2O6S

>98% (HPLC)

DMSO: 10 mM

CN1CCCN=C1/C=C/c2cccs2.c1ccc2c(c1)cc(c(c2Cc3c4ccccc4cc(c3O)C(=O)O)O)C(=O)O

(E)-1,4,5,6-Tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)pyrimidine 4,4'-methylenebis(3-hydroxy-2-naphthoate) (1:1)

(-20℃)

With Ice Pack

≥ 2 years